EURYSTATINS A AND B, NEW PROLYL ENDOPEPTIDASE INHIBITORS I. TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL ACTIVITIES

SOICHIRO TODA; YUMIKO OBI; KEI-ICHI NUMATA; YASUTARO HAMAGISHI; KOJI TOMITA; NOBUJIRO KOMIYAMA; CHIKAKO KOTAKE; TAMOTSU FURUMAI; TOSHIKAZU OKI

doi:10.7164/antibiotics.45.1573

EURYSTATINS A AND B, NEW PROLYL ENDOPEPTIDASE INHIBITORS

I. TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL ACTIVITIES

SOICHIRO TODA, YUMIKO OBI, KEI-ICHI NUMATA, YASUTARO HAMAGISHI, KOJI TOMITA, NOBUJIRO KOMIYAMA, CHIKAKO KOTAKE, TAMOTSU FURUMAI, TOSHIKAZU OKI

著者情報

ジャーナルフリー

1992 年 45 巻 10 号 p. 1573-1579

DOI https://doi.org/10.7164/antibiotics.45.1573

詳細

抄録

Eurystatins A and B, were isolated from the cultured broth of Streptomyces eurythermus R353-21. They showed specific and potent inhibitory activity against prolyl endopeptidase and did not show antimicrobial activity. No lethal toxicity was observed for the two compounds after ip administration in mice at 200 mg/kg.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）