A NEW ANTHRACYCLINE ANTIBIOTIC, CINERUBIN R TAXONOMY, STRUCTURAL ELUCIDATION AND BIOLOGICAL ACTIVITY
1992 年 45 巻 10 号 p. 1599-1608
詳細
1992 年 45 巻 10 号 p. 1599-1608
A novel anthracycline antibiotic, cinerubin R, was isolated from the fermentation broth of Streptomyces eurythermus strain H1715MY2. The structure of cinerubin R was elucidated to be 4"-aculosyl-4"-rhodinosyl-7-rhodosaminyl-ε-pyrromycinone. Cinerubin R was active against Gram-positive bacteria and inhibited the growth of divergent multi-drug-resistant cells to the same extent as their parental cells.
