PRODUCTION OF NEW ANTHRACYCLINE ANTIBIOTICS 1-HYDROXY-OXAUNOMYCIN AND 6-DEOXYOXAUNOMYCIN BY LIMITED BIO-SYNTHETIC CONVERSION USING A DAUNORUBICIN-NEGATIVE MUTANT

AKIHIRO YOSHIMOTO; OSAMU JOHDO; HIROSHI TONE; ROKUROU OKAMOTO; HIROSHI NAGANAWA; TSUTOMU SAWA; TOMIO TAKEUCHI

doi:10.7164/antibiotics.45.1609

AKIHIRO YOSHIMOTO, OSAMU JOHDO, HIROSHI TONE, ROKUROU OKAMOTO, HIROSHI NAGANAWA, TSUTOMU SAWA, TOMIO TAKEUCHI

著者情報

ジャーナルフリー

1992 年 45 巻 10 号 p. 1609-1617

DOI https://doi.org/10.7164/antibiotics.45.1609

詳細

抄録

A limited biosynthetic conversion of some known anthracyclinones using a specific daunorubicin-nonproducing mutant provided four new anthracycline antibiotics: 1-Hydroxy-10-methoxycarbonyl-13-deoxocarminomycin; 1-hydroxy-13-deoxocarminomycin; 1-hydroxyoxaunomycin and 6-deoxyoxaunomycin. Their isolation and purification from bioconversion broth, structural determination and antitumor activities against leukemic L1210 cells are described.

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