PEPTICINNAMINS, NEW FARNESYL-PROTEIN TRANSFERASE INHIBITORS PRODUCED BY AN ACTINOMYCETE I. PRODUCING STRAIN, FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITY

SATOSHI OMURA; DIDIER VAN DER PYL; JUNJI INOKOSHI; YOKO TAKAHASHI; HIDEO TAKESHIMA

doi:10.7164/antibiotics.46.222

PEPTICINNAMINS, NEW FARNESYL-PROTEIN TRANSFERASE INHIBITORS PRODUCED BY AN ACTINOMYCETE

I. PRODUCING STRAIN, FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITY

SATOSHI OMURA, DIDIER VAN DER PYL, JUNJI INOKOSHI, YOKO TAKAHASHI, HIDEO TAKESHIMA

著者情報

ジャーナルフリー

1993 年 46 巻 2 号 p. 222-228

DOI https://doi.org/10.7164/antibiotics.46.222

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抄録

Pepticinnamins A, B, C, D, E and F, a family of farnesyl-protein transferase (FPT) inhibitors were isolated from the fermentation broth of Streptomyces sp. OH-4652. These inhibitors were purified from whole broth by extraction with chloroform, followed by silica gel column chromatography, Sephadex LH-20 chromatography and reverse phase HPLC. Among these, pepticinnamin C showed the most potent inhibition (IC₅₀-100nM).

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