The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
A New Antitumor Antibiotic, BE-19412A, Produced by a Streptomycete
MASAO TSUKAMOTOSHIGERU NAKAJIMAHIROHARU ARAKAWAYASUYUKI SUGIURAHAJIME SUZUKIMIOKO HIRAYAMASEIGO KAMIYAYOSHIHIRO TESHIMAHISAO KONDOKATSUHISA KOJIRIHIROYUKI SUDA
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1998 年 51 巻 10 号 p. 908-914

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A new antitumor substance, designated BE-19412A, was isolated from the culture broth of Streptomyces sp. A19412. The active principle was extracted from the mycelium by methanol and purified by Silica gel and Sephadex LH-20 column chromatographies. BE-19412B was prepared by methylation of BE-19412A. BE-19412A and B exhibited cytotoxic activity against murine and human tumor cell lines. BE-19412A prolonged the survival of CDF1 mice bearing i.p. implanted Ehrlich carcinoma cells.

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