Glucosylquestiomycin, a Novel Antibiotic from Microbispora sp. TP-A0184:
Fermentation, Isolation, Structure Determination, Synthesis and Biological Activities
1998 年 51 巻 10 号 p. 915-920
詳細
1998 年 51 巻 10 号 p. 915-920
Glucosylquestiomycin, a novel N-glucopyranoside of questiomycin A, was isolated from the culture broth of Microbispora sp. TP-A0184. The absolute configuration of the sugar was determined as D-configuration by chemical synthesis. The new antibiotic showed antibacterial activity against Gram-positive and -negative bacteria and yeasts and cytotoxic activity against U937 cells.
