Chemical Modification of Antibiotic Eremomycin at the Asparagine Side Chain

EUGENIA N. OLSUFYEYA; TATIANA F. BERDNIKOVA; OLGA V. MIROSHNIKOVA; MARINA I. REZNIKOVA; MARIA N. PREOBRAZHENSKAYA

doi:10.7164/antibiotics.52.319

EUGENIA N. OLSUFYEYA, TATIANA F. BERDNIKOVA, OLGA V. MIROSHNIKOVA, MARINA I. REZNIKOVA, MARIA N. PREOBRAZHENSKAYA

著者情報

ジャーナルフリー

1999 年 52 巻 3 号 p. 319-324

DOI https://doi.org/10.7164/antibiotics.52.319

詳細

抄録

AA3-Carboxyeremomycin 2, obtained by selective hydrolysis of antibiotic eremomycin was used as a starting compound for the eremomycin chemical modifications at the asparagine side chain to be transformed into eremomycin AA3, AA7 bis-amides (3a-c). Bis-benzylamide 3b displayed an activity (8μg/ml) against an E. faecium VanA strain.

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