6-(Hydroxyalkyl)penicillanates as Probes for Mechanisms of β-Lactamases

DASANTILA GOLEMI; LAURENT MAVEYRAUD; AKIHIRO ISHIWATA; SAMUEL TRAMER; KAZUYUKI MIYASHITA; TSUYOSHI NAGASE; IRINA MASSOVA; LIONEL MOUREY; JEAN-PIERRE SAMAMA; SHAHRIAR MOBASHERY

doi:10.7164/antibiotics.53.1022

DASANTILA GOLEMI, LAURENT MAVEYRAUD, AKIHIRO ISHIWATA, SAMUEL TRAMER, KAZUYUKI MIYASHITA, TSUYOSHI NAGASE, IRINA MASSOVA, LIONEL MOUREY, JEAN-PIERRE SAMAMA, SHAHRIAR MOBASHERY

著者情報

DASANTILA GOLEMI
Department of Chemistry and Institute for Drug Design, Wayne State University
LAURENT MAVEYRAUD
Groupe de Cristallographie Biologique, Institut de Pharmacologie et de Biologic Structurale du CNRS
AKIHIRO ISHIWATA
Department of Chemistry and Institute for Drug Design, Wayne State University
SAMUEL TRAMER
Groupe de Cristallographie Biologique, Institut de Pharmacologie et de Biologic Structurale du CNRS
KAZUYUKI MIYASHITA
Department of Chemistry and Institute for Drug Design, Wayne State University
TSUYOSHI NAGASE
Department of Chemistry and Institute for Drug Design, Wayne State University
IRINA MASSOVA
Department of Chemistry and Institute for Drug Design, Wayne State University
LIONEL MOUREY
Groupe de Cristallographie Biologique, Institut de Pharmacologie et de Biologic Structurale du CNRS
JEAN-PIERRE SAMAMA
Groupe de Cristallographie Biologique, Institut de Pharmacologie et de Biologic Structurale du CNRS
SHAHRIAR MOBASHERY
Department of Chemistry and Institute for Drug Design, Wayne State University

ジャーナルフリー

2000 年 53 巻 10 号 p. 1022-1027

DOI https://doi.org/10.7164/antibiotics.53.1022

詳細

抄録

6-(Hydroxyalkyl)penicillanates have proven helpful as probes for the mechanisms of β-lactamases, enzymes of resistance for β-lactam antibiotics. The present report summarizes the concepts on design, syntheses and use of these molecules in mechanistic studies of β-lactamases.

責任著者(Corresponding author)

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