The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Synthesis and Biological Evaluation of Novel Tricyclic Carbapenems (Trinems)
OSAMU KANNOYASUO SHIMOJISATOSHI OHYAISAO KAWAMOTO
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2000 年 53 巻 4 号 p. 404-414

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Synthesis of new tricyclic carbapenems (trinems) with a pyrrolidinyl moiety at the C-4 position of the tricyclic ring and their antimicrobial activities were studied. These trinems showed potent activities against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA). Among them, (4R)-[(S)-pyrrolidin-3-ylthiomethyl]trinem (14a) exhibited good activity against MRSA in vitro and in vivo.

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