Glomosporin, a Novel Antifungal Cyclic Depsipeptide from Glomospora sp. I. Production, Isolation, Physico-chemical Properties and Biological Activities

TSUTOMU SATO; DAISUKE ISHIYAMA; REIKO HONDA; HISATO SENDA; HIROSHI KONNO; SEIJI TOKUMASU; SUSUMU KANAZAWA

doi:10.7164/antibiotics.53.597

Glomosporin, a Novel Antifungal Cyclic Depsipeptide from Glomospora sp.

I. Production, Isolation, Physico-chemical Properties and Biological Activities

TSUTOMU SATO, DAISUKE ISHIYAMA, REIKO HONDA, HISATO SENDA, HIROSHI KONNO, SEIJI TOKUMASU, SUSUMU KANAZAWA

著者情報

ジャーナルフリー

2000 年 53 巻 6 号 p. 597-602

DOI https://doi.org/10.7164/antibiotics.53.597

詳細

抄録

A novel antifungal cyclic depsipeptide termed glomosporin, which has a fatty acyl side chain, was isolated from a barley solid culture of Glomospora sp. The strain was isolated from fallen pine leaves collected in Fukusima Prefecture, Japan and identified as Glomospora sp. BAUA2825.
Glomosporin was purified by butanol extraction followed by preparative HPLC. Glomosporin showed antimicrobial activity against fungi including clinically important Aspergillus fumigatus.

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