The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Argifin, a New Chitinase Inhibitor, Produced by Gliodadium sp. FTD-0668
II. Isolation, Physico-chemical Properties, and Structure Elucidation
NORIKO ARAIKAZURO SHIOMIYUZURU IWAISATOSHI OMURA
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2000 年 53 巻 6 号 p. 609-614

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抄録
A new chitinase inhibitor, named argifin, was isolated from the cultured broth of a fungal strain Gliodadium sp. FTD-0668. Argifin was purified from the cultured mycelium by the combination of cation exchange, anion exchange, adsorption, and gel filtration chromatographic methods. The structure of argifin was elucidated as cyclo(Nω-(N-methylcarbamoyl)-L-arginyl-N-methyl-L-phcnylalany1-β-l-aspartyl-β-laspartyl-D-alanyl) by NMR experiments and other spectroscopic analyses.
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