FR901469, a Novel Antifimgal Antibiotic from an Unidentified Fungus No.11243 I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Properties

AKIHIKO FUJIE; TOSHIRO IWAMOTO; HIDEYUKI MURAMATSU; TERUMI OKUDAIRA; KUMIKO NITTA; TOMOKO NAKANISHI; KAZUTOSHI SAKAMOTO; YASUHIRO HORI; MOTOHIRO HINO; SEIJI HASHIMOTO; MASAKUNI OKUHARA

doi:10.7164/antibiotics.53.912

FR901469, a Novel Antifimgal Antibiotic from an Unidentified Fungus No.11243

I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Properties

AKIHIKO FUJIE, TOSHIRO IWAMOTO, HIDEYUKI MURAMATSU, TERUMI OKUDAIRA, KUMIKO NITTA, TOMOKO NAKANISHI, KAZUTOSHI SAKAMOTO, YASUHIRO HORI, MOTOHIRO HINO, SEIJI HASHIMOTO, MASAKUNI OKUHARA

著者情報

ジャーナルフリー

2000 年 53 巻 9 号 p. 912-919

DOI https://doi.org/10.7164/antibiotics.53.912

詳細

抄録

FR901469 is a novel antifungal antibiotic produced by an unidentified fungus No.11243. This compound was isolated from the culture broth by solvent extraction, HP-20 and YMC ODS gel column chromatography, and lyophilization. FR901469 is a white powder which melts at 182-187°C and possesses the molecular formula C₇₁H₁₁₆N₁₄O₂₃. This compound has good water solubility. FR901469 inhibited the activity of 1, 3-β-glucan synthase from Candida albicans with an IC₅₀ value of 0.05μg/ml, and displayed greater inhibitory activity than other 1, 3-β-glucan synthase inhibitors such as, WF11899A, echinocandin B, aculeacin A, and papulacandin B.

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