FR171456, a Novel Cholesterol Synthesis Inhibitor Produced by Sporormiella minima No. 15604 II. Biological Activities

HIDETAKA HATORI; TOSHIHIRO SHIBATA; MOTOAKI NISHIKAWA; HIROTSUGU UEDA; MOTOHIRO HINO; TAKASHI FUJII

doi:10.7164/antibiotics.57.260

FR171456, a Novel Cholesterol Synthesis Inhibitor Produced by Sporormiella minima No. 15604

II. Biological Activities

HIDETAKA HATORI, TOSHIHIRO SHIBATA, MOTOAKI NISHIKAWA, HIROTSUGU UEDA, MOTOHIRO HINO, TAKASHI FUJII

著者情報

ジャーナルフリー

2004 年 57 巻 4 号 p. 260-263

DOI https://doi.org/10.7164/antibiotics.57.260

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抄録

Novel cholesterol synthesis inhibitors FR171456 and FR173945 were isolated from the culture broth of Sporormiella minima No. 15604. FR171456 strongly inhibited the cholesterol synthesis and up-regulated the LDL-receptor expression in human hepatoma cell line Hep G2. Single oral administration of FR171456 inhibited in vivo hepatic sterol synthesis in rats. And FR171456 shows a significant serum cholesterol-lowering effect in a cholesterol fed rabbit model.

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