BASIC STUDIES ON 3', 4'-DIDEOXYKANAMYCIN B

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Basic studies were carried out on 3', 4'-dideoxykanamycin B (DKB), a new antibiotic derived from kanamycin B. DKB proved to be highly effective against Klebsiella pneumoniae, Salmonella, and Pseudomonas aeruginosa. DKB showed similar MICs against P. aeruginosa to those of gentamicin (GM). Serum level of DKB reached a peak (38.0 mcg/ml on average) 30 minutes following a single intramuscular injection of 20 mg/kg. Of the injected DKB 63.3% was recovered from the urine within 24 hours. The fact that high levels of DKB were detected in both serum and urine might suggest an excellent therapeutic effects in the treatment of systemic infections as well as urinary infections. The biliary excretion rate of DKB was only 1.22%.