泌尿器科領域におけるAmikacin (BB-K8) の使用経験
1974 年 27 巻 2 号 p. 226-233
詳細
1974 年 27 巻 2 号 p. 226-233
1) Minimal inhibitory concentration of amikacin (BB-K8) was determined on 84 strains isolated from urinary tract infections by the plate dilution method. Many strains of Escherichia coil, Staphylococcus aureus and Pseudomonas tested were inhibited at the concentration of 6.25 mcg/ml or less.
2) In one case with normal renal function, the blood level reached the maximum (25.5 mcg/ml) 30 minutes after intramuscular administration of 200 mg amikacin.
3) The urinary recovery was 82.8% during 6 hours after injection in one normal subject.
4) Thirty-one cases with the complicated urological infections were intramuscularly treated with amikacin 100-400 mg per day. These were 20 cases of chronic pyelonephritis, 7 cases of chronic cystitis and 3 cases of acute prostatitis. Good results were obtained in 20 cases.
5) Side effects were observed in 6 of 31 cases throughout the treatment. Some elevation of serum transaminase was observed in 5 cases and tinnitus and headache in one case. There was no case with abnormal audiogram.
