TOXICOLOGICAL STUDIES ON BESTATIN

II. SUBACUTE TOXICITY TEST AND RECOVERY STUDY IN BEAGLE DOGS

抄録

Bestatin (NK421) is a peptide which was isolated from the fermentation filtrate of Streptomyces olivoreticuli by UMEZAWA and coworkers and inhibits aminopeptidases such as aminopeptidase B or leucine aminopeptidase via antagonistic actions with their substrates.It has been shown to potentiate various immune responses and to exert an antineoplastic action. When used alone or combined with other drugs, NK421 has been shown to possess a promising anticancer effect.
We have already studied the acute toxicity of NK421 in mice, rats and dogs 2 and reported that it shows very low toxicity especially following oral administration.
In the present experiment, we have conducted a subacute toxicity test in male and female Beagle dogs following successive 90times oral dosing and the recovery test following a withdrawal period for5 weeks in an attempt to examine possible toxicological manifestations and confirm the safety of NK421.