TOXICOLOGICAL STUDIES ON A NEW MACROLIDE ANTIBIOTIC, MIDECAMYCIN ACETATE (MIOCAMYCIN)

PART IV-1. TOXICITY OF METABOLITES OF MIOCAMYCIN: ACUTE TOXICITY OF Mb₁ IN MICE

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Miocamycin (MOM) is a derivative of midecamycin, a macrolide antibiotic3, 4) isolated from a culture broth of Streptomyces mycarofaciens1, 2). MOM is metabolized into 4 main metabolites of Mb₁, Mb₂, Mb₅, and Mb₁₂5).
The object of this study was to evaluate acute toxicity in male and female mice after single oral administration of Mb₁, a metabolite of MOM, at a dose level of 5,000 mg/kg as the maximum physically applicable dose.
Observations were kept for I week after administration. In conclusion, Mb₁ exhibited no acute toxicity in present study.
The LID₀ values were estimated as more than 5,000 mg/kg.