TOXICOLOGICAL STUDIES ON A NEW MACROLIDE ANTIBIOTIC, MIDECAMYCIN ACETATE (MIOCAMYCIN)

PART IV-8. TOXICITY OF METABOLITES OF MIOCAMYCIN: ACUTE TOXICITY OF Mb₆ IN RATS

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Miocamycin (MOM) is a derivative of midecamycin1, 2) and is metabolized into 4 main metabolites of Mb₁, Mb₂, Mb₆ and Mb₁₂5).
In the previous studies, we estimated LD₅₀ values of Mb₆ in male and female mice7) after single oral administration. The LD₅₀ values were 4, 150mg/kg in male mice and 4,000mg/kg in female mice, respectively.
In the present studies, we evaluated acute toxicity and estimated LD₅₀ values of Mb₆ in male and female rats after single oral administration.
Observations were continued for 1 week after treatment.
It is concluded that LD₀ values of Mb₆ in male and female rats, were estimated more than 5,000mg/kg as Mb₆ did not exhibit any manifest acute toxicity even at the maximum physically applicable dose of 5,000mg/kg.