TOXICOLOGICAL STUDIES ON A NEW MACROLIDE ANTIBIOTIC, MIDECAMYCIN ACETATE (MIOCAMYCIN) PART IV-9. TOXICITY OF METABOLITES OF MIOCAMYCIN: SUBACUTE TOXICITY OF Mb<SUB>6</SUB> IN RATS

MASAYUKI YOKOTA; UETO TAKEDA; MASUZO ODAKI; HITOSHI SASAKI; TETSUTARO NIIZATO; HARUO KAWAOTO; HIROSHI WATANABE; NOBUYOSHI ISHIWATARI; HIROYASU HAYASAKA; TAKEMI KOEDA

doi:10.11553/antibiotics1968b.37.1532

TOXICOLOGICAL STUDIES ON A NEW MACROLIDE ANTIBIOTIC, MIDECAMYCIN ACETATE (MIOCAMYCIN)

PART IV-9. TOXICITY OF METABOLITES OF MIOCAMYCIN: SUBACUTE TOXICITY OF Mb₆ IN RATS

MASAYUKI YOKOTA, UETO TAKEDA, MASUZO ODAKI, HITOSHI SASAKI, TETSUTARO NIIZATO, HARUO KAWAOTO, HIROSHI WATANABE, NOBUYOSHI ISHIWATARI, HIROYASU HAYASAKA, TAKEMI KOEDA

著者情報

MASAYUKI YOKOTA
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd
UETO TAKEDA
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd
MASUZO ODAKI
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd
HITOSHI SASAKI
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd
TETSUTARO NIIZATO
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd
HARUO KAWAOTO
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd
HIROSHI WATANABE
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd
NOBUYOSHI ISHIWATARI
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd
HIROYASU HAYASAKA
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd
TAKEMI KOEDA
Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd

ジャーナルフリー

1984 年 37 巻 8 号 p. 1532-1545

DOI https://doi.org/10.11553/antibiotics1968b.37.1532

詳細

抄録

Miocamycin (MOM) is a derivative of midecamycin and is metabolized into 4 main metabolites of Mb₁, Mb₂, Mb₆ and Mb₁₂(5). It is also known that LD₅₀ values of Mb₆ were 4, 150mg/kg in male mice⁸ and 4,000mg/kg in female mice but LD₀ values in male and female rats were estimated more than 5,000mg/kg.6) The object of this study was to examine subacute toxicological effects in male and female rats after repeated oral administration of Mb₆ for 5 weeks at a daily dosage of 125, 250, 500 and 1,000mg/kg. It is concluded that no manifest toxicity was observed in this study with Mb₆ in male and female rats after oral administration at dosage levels of 125, 250, 500 and 1,000mg/kg for 5 weeks.

責任著者(Corresponding author)

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