TOXICOLOGICAL STUDIES ON A NEW MACROLIDE ANTIBIOTIC, MIDECAMYCIN ACETATE (MIOCAMYCIN)

PART VI-1. ACUTE TOXICITY IN INFANT MICE IN COMPARISON WITH YOUNG ADULT MICE

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SUTHERLAND1) and WEISS et al.7) reported cases of newborn human deaths or GRAY syndrome after overdosage of chloramphenicol. In general, it has been reported that the acute toxicities of drugs are enhanced in immature animals compared with adult animals.
The objective of this study was to determine the LD₅₀ values in infant (5-day-old) and young adult (5-week-old) male and female mice after single subcutaneous and oral administration of MOM, noncrystalline solid and to estimate the toxicity ratio of those LD₅₀ values.
LD50 values of MOM, non-crystalline solid, were more than 5,000mg/kg and the lethal toxicity was the same in infant and adult mice. Toxicity ratios were not obtained.