TOXICOLOGICAL STUDIES ON A NEW MACROLIDE ANTIBIOTIC, MIDECAMYCIN ACETATE (MIOCAMYCIN)

PART VI-2. ACUTE TOXICITY IN INFANT RATS IN COMPARISON WITH YOUNG ADULT RATS

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In the present acute toxicity studies on MOM, non-crystalline solid, with infant male and female rats (5-day-old) and young adult male and female rats (5-week-old), it is confirmed as follows:
1. LD₅₀ values were estimated more than 5,000mg/kg in both cases of subcutaneous and oral administrations.
2. MOM, non-crystalline solid, did not exhibit any toxic effects similarly as previously reported with infant male and female mice and young adult male and female mice.
3. There might be no definite age difference in toxicity between young and adult rats as LD₅₀ values were estimated more than 5,000mg/kg in independence upon the age.
4. There might be no definite species difference in toxicity between mice1) and rats.