EFFECTS OF MIDECAMYCIN ACETATE (MIOCAMYCIN), A NEW MACROLIDE ANTIBIOTIC, ON REPRODUCTIVE PERFORMANCES IN RATS AND RABBITS

抄録

Miocamycin (MOM) is a derivative of midecamycin, a macrolide antibiotic isolated from a culture broth of Streptomyces mycarofaciens. The objective of this study was to determine the effect of MOM on reproductive performance in rats and rabbits. MOM, non-crystalline solid, was suspended in 0.1% CMC solution immediately before use.
In this study, reproductive performance was studied according to the following designs:
1. Fertility test (Segment I) in Wistar rats
2. Teratogenicity test (Segment II) in Wistar rats
3. Peri-and post-natal tests (Segment III) in Wistar rats
4. Behavioral test in rat newborns in Segments II and III
5. Teratogenicity test (Segment II) in New Zealand white rabbits
In conclusion, MOM, non-crystalline solid, might have no teratogenesis and little influence on dams and their fetuses and offsprings.