THE ANTIMICROBIAL ACTIVITY IN VITRO OF CEFPIROME AND 6 OTHER β-LACTAM ANTIBACTERIAL AGENTS AGAINST CLINICAL ISOLATES

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The in vitro activity of cefpirome (CPR) was compared with that of cefazolin (CEZ), cefotiam (CTM), flomoxef (FMOX), cefotaxime (CTX), ceftazidime (CAZ) and imipenem/cilastatin (IPM/CS) against 384 clinical isolates, for tested by the broth microdilution method. The activity of CPR against Staphylococcus aureus (MIC₅₀, 1 μg/ml) and Enterococcus faecalis (MIC₅₀), 8 μg/ml) was better than CTX and CAZ, but slightly less than IPM/CS. CPR and other antibacterial agents were not effect against methicillin resistant S. aureus and Enterococcus faecium. The activity of CPR against Enterobacteriaceae was as good as that of CTX, CAZ, and IPM/CS, and more effective than CEZ, CTM and FMOX. The MIC₅₀ of CPR for Acinetobacter calcoaceticus (2 μg/ml) and the MIC₅₀ of CPR for Pseudomonas aeruginosa (8 μg/ml) were as good as that of CAZ. Conclusionly, CPR was a new broad spectrum cephalosporin as compared with used cephalosporins.