On the Effects of Gastric Hormone “Productin” on the Liver Cells

Abstract

The authors have searched the effects of productin (FUJIE), a gastric hormone, on the liver cells. For this purpose, the authors have performed the following experiments: 1. sesame oil (37°C, 1cc.) was instilled into the stomach of starved rats, 2. the same administration of sesame oil was performed after ligation of the pylorus, 3. histamine (3mg) was injected subcutaneously into starved rats, and 4. 2hrs. after sesame oil administration, histamine was injected subcutaneously. Then the authors have analysed histamine in the blood quantitatively, and observed the plastosomes in the liver cells.
It has been demonstrated, according to the results obtained in each experiment, that the thickening and the changes of the forms of plastosomes in the liver cells have a relationship with the quantity of histamine in the blood. Regardless of a giving or not giving sesame oil or even of a starvation, cells showed active functional figures, with thick plastosomes, when there was a large amount of histamine in the blood, on the other hand, most of the plastosomes were long rod-shaped, when the histamine in the blood decreased. The phenomena have no relation with metabolic substances in the cells. Therefore the thickening and granulating of the plastosomes hardly occurred by the acting of sesame oil itself, but might have been brought about by productin (histamine) which is secreted from the gastric mucosa followed by instilling of sesame oil.