When buffer nerves are cut in rabbits the adrenal cortex shows a similar finding as after injection ACTH, even after two months. That is, the cells of zona fasciculata becomes small, there is a remarkable appearance of dark tone cells, the sinusoids widens, crevises appears, and there is a decrease of lipoid in the zona fasciculata. Furthermore, the number of cells named after their characteristic micro-structure, type I, II, III and IV becomes about the same. With a simple operative procedure the findings in the adrenal cortex return to its normal condition within a month.
The point is, sectioning buffer nerves does not just temporary activate the function of the adrenal cortex, as injecting ACTH or operative procedures, but is characteristic by influencing the cortical cells for a long period.