アナフィラキシーに関する薬理学的研究 : 第4報 卵白アナフィラキシーと自律神経機能および副腎機能の相関について

抄録

Rabbits and guinea pig were sensitized with egg-white and shocked by the injection of the antigen. The shock was neither prevented nor weakened by cutting vagal nerves, extirpation of Ggl. stellata or artificial respiration. The death due to shock was sometimes prevented, when the blood-pressure was kept so as not to be falled by the continuous infusion of 10^<-5>g/ml adrenalin. These facts suggest that autonomic nervous system may have not an important role in anaphylactic shock, but the antigen-antibody reaction in center and wall of blood-vessel may be the main cause of it. In the sensitized rabbit, no evident change was observed before shock in the reaction to adrenaline and acetylcholine. In the guinea pigs extirpated the left adrenal, anaphylactic shock was provoked as severe as in the guinea pig non-extirepated by the intravenous injection of antigen, but the shock was provoked by the intraperitoneal injection. Schultz-Dale's reaction with the intestine of the sensitized guinea pig adrenalectomized was largely weakened than the reaction in the control.