抗原の吸入による喘息の誘発試験についての一考察

抄録

Inhalative provocation test is the excellent diagnostic method to detect the causative agent of bronchial asthma but the possibility of its danger due to possible pulmonary stretch reflex or anaphylactic shock has always been annoying. To investigate this aspect, acute distension of the lung was produced in 10 dogs by the way of deviced expiratory resistance. No dramatic change in electrocardiogram was observed unless hypoxia was kept long. Even if there occurred some changes such as extrasystole, wandering pace maker, bradycardia etc, it reversed quite easily when the distension of the lung was relieved. Considering our past clinical experience and this result, it was postulated that the test can be carried out quite safely unless patient has significant cardiac diseases.