こんにやく喘息の血清学的研究 : 第三報 こんにやく喘息モルモットにおけるまいこ血中抗体及び, まいこ組織抗体について

抄録

In the past many experiments were demonstrated by Shichijo and associates, that the asthmatic attack by the inhalation with Maiko in the guinea pigs was similar to the asthmatic attack in the patients of the Konjac Asthma. In the present studies the author presented to clarify serologically the nature of the asthmatic attack in the guinea pigs with Maiko. The results obtained were as follows : l) The circulating antibody against Maiko by means of tanned cell hemagglutination test; and the cell-fixed antibody against Maiko by use of Schultz-Dale reaction were demonstrated in the asthmatics and non-asthmatics exposed to Maiko after 14-21 days exposure to Maiko. 2) The hemagglutinating antibody against Maiko was found in the serum of the almost all asthmatics as well as non-asthmatics inhalated to Maiko. However cell-fixed antibody against Maiko by means of Schultz-Dale reaction was demonstrated in the all subjects of the asthmatics 3) In the guinea pigs exposed to Maiko the count of the eosinophile cell in the blood were significantly changed comparing to that of healthy guinea pigs without exposure to Maiko, but on the eosinophil count, not a difference was observed between the asthmatics and non-asthmatics. From these findings the author assumed that the antibodies against Maiko in the asthmatic attack in the animals seems to be more related to cell-fixed antobody than circulating antibody. And the author assumed that the variation of the eosinophile cell in the animals with exposure to Maiko was due to the allergic reaction as above-mentioned antibodies against Maiko.