補体系の病態生理に関する研究 : 第1報. 血清補体活性, 血清補体第1成分活性および細胞結合性補体第1成分活性に関する臨床的研究.

抄録

The present author examined serum hemolytic activity, immune adherence (I A) activity, C'1 activity and cell bound C'1 activity in cases of various diseases according to the methods of Mayer, Nishioka, Borsos et al., respectively. (1) In normal male adults, the serum hemolytic activity was (36.37 ± 0.80) C'H50/ml, the I A activity (5.5 ± 0.2) ×10^3 C'IA50/ml, the C'1 activity (3.24 ± 0.29) × 10^4 C'IH_<63>/ml and the bone marrow cell bound C'1 activity (16.0 ± 5.9) SFU/Cell. In normal females, the serum hemolytic activity was (33.30 ± 0.96) C'H50/ml, the IA activity (4.9 ± 0.4) × 10^3 C'1 A50/ml, the C'1 activity (4.33 ± 0.70) × 10^4 C'1 H_<63>/ml and the cell bound C'1 activity (22.3 ± 8.5) SFU/Cell, respectively. The serum hemolytic activity was significantly higher in normal male adults than in normal females (P<0.05). The differences, however, in the I A, C'1 and bound C'1 activities between the sexes were not statistically significant. (2) In 98 cases of various patients and normal persons, the hemolytic activity was recognized to be limited by one or more of the early acting components (C'1, 4, 2, 3), when the I A activity was below 6.0 × 10^3 C'IA50/ml, and to be limited by one or more of the late acting components (C'5, 6, 7, 8, 9), when the I A activity was above 8.0 × 10^3 C'IA50/ml. Definite correlations were detected between the I A and C'1 activities (r= + 0.505), and between the C'1 and bound C'1 activities (r= - 0.322). No correlation was detected, however, between the hemolytic and C'1 activities, between the hemolytic and bound C'1 activities or between the I A and bound C'1 activities. Serum hemolytic, I A, C'1 activities and cell bound C'1 activitywere estimated in 218 cases of various diseases. The results were as follows. (3) High serum hemolytic, I A, C'1 and varied bone marrow cell bound C'1 activities in cases of acute myelogeneous leukemia, and a high hemolytic activity cases of chronic myelogeneous leukemia, were observed. The serum hemolytic, I A, C'1 activities and the cell bound C'1 activity showed more marked fluctuations in acute leukemia than in chronic leukemia. A reduction in the cell bound C'1 activity and an elevation in the serum hemolytic, I A and C'1 activities in cases of acute leukemia were observed during the treatments with corticosteroid or and 6-MP. (4) In cases of Banti's syndrome, low serum hemolytic, I A activities and a considerably high bone marrow cell bound C'1 activity were detected. In cases of acquired hemolytic anemia, a low hemolytic activity and normal I A and C'1 activities were observed. In cases of idiopathic thrombocytopenic purpura, hemolytic, I A and C'1 activities were proved to be nearly normal. A lower hemolytic activity and a higher bound C'1 activity were detected in cases with splenomegaly. A lower hemolytic activity was observed at the stage of reticulocytocrisis. Lower hemolytic, I A, C'1 activities and a higher bound C'1 activity were seen in cases with positive Coombs' test. Lower hemolytic and I A activities were recognized in cases with complication of the impaired liver function. Lower serum hemolytic, I A, C'1 activities and a higher bone marrow cell bound C'1 activity were detected at the stage of relapse, while higher serum hemolytic, I A, C'1 activities and a lower cell bound C'1 activity were found at the stage of remission. (5) High hemolytic, I A and C'1 activities were affirmed in cases of myocardial infarction. (6) A significantly high I A activity in cases of peptic ulcer and high hemolytic, I A activities in cases of ulcerative colitis were detected. (7) Relatively higher hemolytic, I A and C'1 activities in cases of acute hepatitis and a

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