免疫細胞としての小リンパ球 : 特に抗原刺戟によるその Blastogenesis について

抄録

Small lymphocytes are located in blood and immune organs as immunologically competent cell, and differentiate to the performing immunocytes by antigenic stimulation. The performing immunocytes are two in type; the one produces immunoglobulins and engage the humoral immune reactions, which is "plasma cell", and the other engages the cellurar immune reaction by themselves, which is small lymphocyte. As the first step of the differentiation, the small lymphocyte is transformed to large cell or less differentiated cell. Peripheral lymphocytes from sensitized person are transformed to large cells or less differentiated cells in vitro, when they are cultured with sensitizing antigen. This is called "Lymphocytic Blastogenesis by Antigenic Stimulation", and is condidered to be the first step of the differentiation discussed above. This phonomena is observed in various immunological states, not only of the immediate type but also of the delayed type. We have demonstrated this in bronchial of house dust allergen. Leukemoid reaction might be a manifestation of hyperreactive state of the blasogenesis, while Ataxia-teleangiectasis the hyporeactive state of the lymphocytes. As one of immunological investigations this type of cytological and dynamic apporoach is important.