A Case of Diffuse Large B-cell Lymphoma of the Lung Demonstrating Diffuse Ground-glass Shadows

Saiko Ogata-Suetsugu; Takashige Maeyama; Masafumi Takeshita; Naoki Hamada; Koichi Takayama; Hiromasa Inoue; Yoichi Nakanishi

doi:10.5761/atcs.cr.10.01651

Case Reports

A Case of Diffuse Large B-cell Lymphoma of the Lung Demonstrating Diffuse Ground-glass Shadows

Saiko Ogata-Suetsugu, Takashige Maeyama, Masafumi Takeshita, Naoki Hamada, Koichi Takayama, Hiromasa Inoue, Yoichi Nakanishi

Author information

Saiko Ogata-Suetsugu
Research Institute for diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka, Japan
Takashige Maeyama
Research Institute for diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka, Japan
Masafumi Takeshita
Research Institute for diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka, Japan
Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka, Japan
Naoki Hamada
Research Institute for diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka, Japan
Koichi Takayama
Research Institute for diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka, Japan
Hiromasa Inoue
Research Institute for diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka, Japan
Yoichi Nakanishi
Research Institute for diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka, Japan

Keywords: primary pulmonary lymphoma (PPL), diffuse ground-glass shadows, immunoglobulin heavy chain gene rearrangement

JOURNAL FREE ACCESS

2011 Volume 17 Issue 6 Pages 591-594

DOI https://doi.org/10.5761/atcs.cr.10.01651

View "Advance Publication" version (August 17, 2011).

Details

Abstract

We report a case of 77-year-old woman suffering from breathlessness on exertion and dry cough. Chest computed tomography (CT) showed diffuse ground-glass shadows. A video-assisted thoracoscopic lung biopsy resulted in the diagnosis of diffuse large B-cell lymphoma (DLBCL). Gene rearrangement analysis using polymerase chain reaction (PCR) technique was performed on the cells in bronchoalveolar lavage (BAL) fluid, and showed the clonality of the immunoglobulin heavy chain (IgH) gene, supporting the diagnosis. DLBCL should be considered in the differential diagnosis of diffuse ground-glass shadows in the chest CT, and gene rearrangement analysis may have an impact on the diagnosis of pulmonary DLBCL.

Corresponding author

Register with J-STAGE for free!