Biological Activities of (1→3)-β-D-Glucans with Reducing Glucose Side Chains

Abstract

  Newly synthesized (1→3)-β-D-glucans with reducing glucose side chains (6-O-glucopyranosylated curdlan and 3-O-glucopyranosylated curdlan, with glucose linked directly (except for anomeric carbon) had antitumor activity against mice sarcoma 180 in mice. The two glucans potentiated the reticuloendotheliai system and activated macrophages (increased their glucose consumption). The activity inducing tumor regressing factor of the glucan derivatives was stronger than a linear (1→3)-β-D-glucan (curdlan).