Asymmetric Reduction of Ethyl 2-methyl 3-oxobutanoate by Chlorella

Takayuki KURAMOTO; Kenzo IWAMOTO; Minoru IZUMI; Mitsunori KIRIHATA; Fumiki YOSHIZAKO

doi:10.1271/bbb.63.598

Microbiology & Fermentation Technology Notes

Asymmetric Reduction of Ethyl 2-methyl 3-oxobutanoate by Chlorella

Takayuki KURAMOTO, Kenzo IWAMOTO, Minoru IZUMI, Mitsunori KIRIHATA, Fumiki YOSHIZAKO

著者情報

キーワード: Chlorella, asymmetric reduction, ethyl 2-methyl 3-oxobutanoate, (2S, 3S)-ethyl 2-methyl 3-hydroxybutanoate, (2S, 3R)-ethyl 2-methyl 3-hydroxybutanoate

ジャーナルフリー

1999 年 63 巻 3 号 p. 598-601

DOI https://doi.org/10.1271/bbb.63.598

詳細

抄録

Chlorella pyrenoidosa Chick reduced ethyl 2-methyl 3-oxobutanoate to the corresponding alcohols with the diastereomer (anti/syn) ratio of 53/47. The enantiomer excesses of anti-(2S, 3S)- and syn-(2S, 3R)-hydroxy esters were 89 and >99ee% respectively. C. vulgaris and C. regularis afforded predominantly the syn-isomer, contrary to C. pyrenoidosa. The differences in the activity of reducing ethyl 2-methyl 3-oxobutanoate were observed among three strains of Chlorella. Addition of 2% metal salts slightly increased the chemical yield of the hydroxy ester.

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