Synthesis of 4′-C-Ethynyl-β-<small>D</small>-ribo-pentofuranosyl Pyrimidines

Ritsuko YAMAGUCHI; Tatsuma IMANISHI; Satoru KOHGO; Hiroko HORIE; Hiroshi OHRUI

doi:10.1271/bbb.63.736

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Organic Chemistry Regular Papers

Synthesis of 4′-C-Ethynyl-β-D-ribo-pentofuranosyl Pyrimidines

Ritsuko YAMAGUCHI, Tatsuma IMANISHI, Satoru KOHGO, Hiroko HORIE, Hiroshi OHRUI

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Keywords: 4′-C-substituted nucleosides, ethynyl group

JOURNAL FREE ACCESS

1999 Volume 63 Issue 4 Pages 736-742

DOI https://doi.org/10.1271/bbb.63.736

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Abstract

The 4′-C-ethynyl-β-D-ribo-pentofuranosylpyrimidines were prepared from D-glucose through properly protected 4′-C-formyl-D-ribo-ribofuranose as the key intermediate, and preliminary biological tests against some viruses and tumor cells showed that the compounds were not active.

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