Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Biochemistry & Molecular Biology Regular Papers
Effects of Rat Fetuin on Stimulation of Bone Resorption in the Presence of Parathyroid Hormone
Osamu NAKAMURAJamil Ahsan KAZITomokazu OHNISHINaokatu ARAKAKIQing SHAOTakehiro KAJIHARAYasushi DAIKUHARA
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1999 Volume 63 Issue 8 Pages 1383-1391

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Abstract

  Rat fetuin, which is the rat counterpart of human α2-HS glycoprotein and bovine fetuin, is only detectable in calcified tissues such as bone matrices and dentin, and bone cells such as osteoblasts and osteocytes immunohistochemically. The effect of this protein on bone resorption was examined to study its physiological role in bone metabolism. Rat fetuin increased bone resorption in the presence of low concentrations of parathyroid hormone (PTH), but it had no activity on bone resorption without PTH. The increase in bone resorption by PTH and PTH plus rat fetuin was inhibited by the addition of chymostatin, an inhibitor for cathepsin L. Moreover, we found that when type I collagen from rat was preincubated with rat fetuin, the digestion of rat type I collagen by cathepsin L was increased. These findings suggest that rat fetuin present in bone matrix is important in bone resorption.

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© 1999 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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