Inhibition by (-)-Persenone A-related Compounds of Nitric Oxide and Superoxide Generation from Inflammatory Leukocytes

Abstract

  We have previously reported that persenone A, isolated from avocado fruit, is an effective inhibitor of both nitric oxide (NO) and superoxide (O₂^-) generation in cell culture systems. In this study, we have prepared four persenone A-related compounds and examined their inhibition of NO and O₂^- generation from inflammatory leukocytes. Some structural importance in persenone A to attenuate free radical generation is discussed.