Organic Chemistry Notes
Novel Fungal Metabolites, Demethylsorbicillin and Oxosorbicillinol, Isolated from Trichoderma sp. USF-2690
2000 年 64 巻 3 号 p. 620-622
詳細
2000 年 64 巻 3 号 p. 620-622
The novel compounds, demethylsorbicillin (1) and oxosorbicillinol (2), were isolated from a fermentation broth of Trichoderma sp. USF-2690. The structures of these compounds, which were determined from spectroscopic evidence, suggest the possibility that methylation at C-6 and oxidation at C-1 and C-6 of sorbicillin were controlled in the early polyketide stage before the formation of oxidized sorbicillin dimers. In a 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging assay, 2 gave an ED50 value of 87.7 μM.
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