2000 Volume 64 Issue 5 Pages 1047-1051
The effects of oxidized cholesterol on immune parameters were examined by using spleen lymphocytes and peritoneal exudate cells (PEC) derived from 5-week- (Young) and 9-month-old (Adult) rats. The immunoglobulin (Ig) G and IgM production was inhibited by oxidized cholesterol in the rats of both ages when lymphocytes were exposed to 30 μg/ml of oxidized cholesterol for 24 hr. The intracellular IgA level was also lowered by 30 μg/ml of oxidized cholesterol, irrespective of age. In contrast, IgE production was significantly increased by the addition of 30 μg/ml of oxidized cholesterol in only young lymphocytes. Moreover, oxidized cholesterol enhanced the intracellular histamine accumulation in only adult PEC, although the total histamine level produced by PEC was similar in the rats of both ages. These results thus suggest the possibility that oxidized cholesterol can have different effects on the age-related modulation of immune functions such as Igs production and histamine release.
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