Non-effect of Hexamethonium, a Ganglionic Blocker, on the Response of Ileal Apolipoprotein A-IV mRNA Following a Massive Small Bowel Resection in Rats

Abstract

  An intravenous infusion of hexamethonium, a ganglionic blocker, did not affect the increase in the apolipoprotein A-IV mRNA level in the residual ileum following a massive small bowel resection in unrestrained conscious rats. The result suggests that upregulation of the apolipoprotein A-IV gene in the residual ileum is not mediated by a neural pathway, including the nicotinic synapse route.