Application of a Single-cell Gel Electrophoresis (Comet) Assay to Screen the Antimutagenic Activity in Foods

Misao MIWA; Yasuhisa HONGO

doi:10.1271/bbb.64.1292

抄録

Three cell lines (HL60, U937 and RAW264.7) were studied for their sensitivity against mutagens by using a single-cell gel electrophoresis (comet) assay. RAW264.7, the most sensitive one, was chosen to screen the antimutagenic activity in swine and bovine offal. Aqueous extracts of the swine stomach (0.2 mg/ml) and heart (10 mg/ml) were found to have antimutagenic activity against MeIQx (+S9mix)-treated cells.

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前身誌

Bulletin of the Agricultural Chemical Society of Japan

Agricultural and Biological Chemistry

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