Effects of Bacterial Glyceroglycolipid M874B on Growth and TPA-Induced Differentiation of HL60 Cells

Motoko MATSUFUJI; Yasunori NAGAMATSU; Akihiro YOSHIMOTO

doi:10.1271/bbb.64.1302

Biochemistry & Molecular Biology Notes

Effects of Bacterial Glyceroglycolipid M874B on Growth and TPA-Induced Differentiation of HL60 Cells

Motoko MATSUFUJI, Yasunori NAGAMATSU, Akihiro YOSHIMOTO

著者情報

キーワード: glyceroglycolipid, oxygen radical scavenger, HL60 cell, differentiation

ジャーナルフリー

2000 年 64 巻 6 号 p. 1302-1304

DOI https://doi.org/10.1271/bbb.64.1302

詳細

抄録

Bacterial monogalactosyldiacylglycerol M874B (MGDAG), which protects against oxygen radicals, was found to increase the growth of the human promyelocytic leukemia cell HL60 when added to the cell culture, but suppresses the 12-O-tetradecanoyl phorbol-13-acetate-induced differentiation. Analogous MGDAG, S365B had weak, but similar effects. These activities were not observed with analogous plant glyceroglycolipids and diacylglycerol.

責任著者(Corresponding author)

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