Inhibition of Telomerase Activity by Fungus Metabolites, CRM646-A and Thielavin B

Ken-ichi TOGASHI; Hack-Ryong KO; Jong-Seog AHN; Hiroyuki OSADA

doi:10.1271/bbb.65.651

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Organic Chemistry

Inhibition of Telomerase Activity by Fungus Metabolites, CRM646-A and Thielavin B

Ken-ichi TOGASHI, Hack-Ryong KO, Jong-Seog AHN, Hiroyuki OSADA

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Keywords: screening, telomerase, CRM646-A, thielavin B, reverse transcriptase

JOURNAL FREE ACCESS

2001 Volume 65 Issue 3 Pages 651-653

DOI https://doi.org/10.1271/bbb.65.651

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Abstract

We performed a screening program to identify telomerase inhibitors from our drug source obtained from fungus fermentations, and found that two compounds, CRM646-A and thielavin B, inhibited telomerase activity at doses of 3.2 and 32 μM, respectively. These compounds also inhibited the activity of viral reverse transcriptase at almost the same dose levels which inhibited telomerase activity.

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