Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Food & Nutrition Science
Suppression of Lipopolysaccharide-induced Liver Injury by Various Types of Tea and Coffee in D-Galactosamine-sensitized Rats
Puming HEYasuhiro NODAKimio SUGIYAMA
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2001 年 65 巻 3 号 p. 670-673

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Extracts of various types of tea and coffee significantly suppressed lipopolysaccharide (LPS)-induced liver injury, as assessed by the plasma enzyme activities, in D-galactosamine-sensitized rats when administered orally once before injecting the drugs. These was a significant negative correlation between the caffeine levels of these extracts and liver injury. Authentic caffeine also had a hepatoprotective effect. These results suggest that caffeine-containing beverages generally suppress LPS-induced liver injury according to their caffeine content.
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© 2001 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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