Anti-tumor Promoting Activity of Bufadienolides from Kalanchoe pinnata and K. daigremontiana × butiflora

Unang SUPRATMAN; Tomoyuki FUJITA; Kohki AKIYAMA; Hideo HAYASHI; Akira MURAKAMI; Hirofumi SAKAI; Koichi KOSHIMIZU; Hajime OHIGASHI

doi:10.1271/bbb.65.947

Food & Nutrition Science

Anti-tumor Promoting Activity of Bufadienolides from Kalanchoe pinnata and K. daigremontiana × butiflora

Unang SUPRATMAN, Tomoyuki FUJITA, Kohki AKIYAMA, Hideo HAYASHI, Akira MURAKAMI, Hirofumi SAKAI, Koichi KOSHIMIZU, Hajime OHIGASHI

著者情報

キーワード: bufadienolide, Epstein-Barr virus, anti-tumor promoter, Kalanchoe pinnata, Kalanchoe daigremontiana×tubiflora

ジャーナルフリー

2001 年 65 巻 4 号 p. 947-949

DOI https://doi.org/10.1271/bbb.65.947

詳細

抄録

Five bufadienolides (1-5) isolated from the leaves of Kalanchoe pinnata and K. daigremontiana×tubiflora (Crassulaceae) were examined for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation in Raji cells induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate. All bufadienolides showed inhibitory activity, and bryophyllin A (1) exhibited the most marked inhibition (IC₅₀=0.4 μM) among the tested compounds. Bryophyllin C (2), a reduction analogue of 1, and bersaldegenin-3-acetate (3) lacking the orthoacetate moiety were less active. These results strongly suggest that bufadienolides are potential cancer chemopreventive agents.

責任著者(Corresponding author)

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