Pentalenolactone I and Hygromycin A, Immunosuppressants produced by Streptomyces filipinensis and Streptomyces hygroscopicus

Masaru UYEDA; Masafumi MIZUKAMI; Kazumi YOKOMIZO; Keitarou SUZUKI

doi:10.1271/bbb.65.1252

Biochemistry & Molecular Biology

Pentalenolactone I and Hygromycin A, Immunosuppressants produced by Streptomyces filipinensis and Streptomyces hygroscopicus

Masaru UYEDA, Masafumi MIZUKAMI, Kazumi YOKOMIZO, Keitarou SUZUKI

著者情報

キーワード: Streptomyces, pentalenolactone I, hygromycin A, immunosuppressant, interleukin

ジャーナルフリー

2001 年 65 巻 5 号 p. 1252-1254

DOI https://doi.org/10.1271/bbb.65.1252

詳細

抄録

Immunosuppressants isolated from Streptomyces filipinensis and S. hygroscopicus were identified with pentalenolactone I and hygromycin A, respectively. The compounds as well as cyclosporin A showed immunosuppressant activity in the mixed lymphocyte reaction, and pentalenolactone I and cyclosporin A suppressed IL-2 production, however, hygromycin A did not. Hygromycin A may have immunosuppressant activity by a different mechanism from pentalenolactone I, cyclosporin A and tacrolimus.

責任著者(Corresponding author)

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