Inhibitory Effect of Monoacylglycerol on Fatty Acid Uptake into Rat Intestinal Epithelial Cells

Kaeko MUROTA; Noriko MATSUI; Teruo KAWADA; Nobuyuki TAKAHASHI; Tohru FUSHUKI

doi:10.1271/bbb.65.1441

Food & Nutrition Science

Inhibitory Effect of Monoacylglycerol on Fatty Acid Uptake into Rat Intestinal Epithelial Cells

Kaeko MUROTA, Noriko MATSUI, Teruo KAWADA, Nobuyuki TAKAHASHI, Tohru FUSHUKI

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Keywords: long-chain fatty acid, monoacylglycerol, intestinal absorption, IEC-6

JOURNAL FREE ACCESS

2001 Volume 65 Issue 6 Pages 1441-1443

DOI https://doi.org/10.1271/bbb.65.1441

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Abstract

We investigated the influence of glycerol esters on oleic acid uptake into IEC-6 cells. Monoolein, especially 2-monoacylglycerol, significantly inhibited the cellular uptake. Although diolein slightly inhibited the oleic acid uptake, triolein, glycerol and monooctanoate had no effect. These results suggest that after lipid digestion in the intestine, long-chain fatty acid uptake may be influenced by another digestive product, 2-monoacylglycerol.

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