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Bioscience, Biotechnology, and Biochemistry
Vol. 66 (2002) No. 12 P 2683-2686



Biochemistry & Molecular Biology Notes

  In an investigation of the mechanisms of the neuroprotective effects of theanine (γ-glutamylethylamide) in brain ischemia, inhibition by theanine of the binding of [3H](RS)-α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), [3H]kainate, and [3H](E)-3-(2-phenyl-2-carboxyethenyl)-4,6-dichloro-1-H-indole-2-carboxylic acid (MDL 105,519) to glutamate receptors was studied in terms of its possible inhibiting effects on the three receptor subtypes (AMPA, kainate, and NMDA glycine), with rat cortical neurons. Theanine bound the three receptors, but its IC50 of theanine was 80- to 30,000-fold less than that of L-glutamic acid.

Copyright © 2002 by Japan Society for Bioscience, Biotechnology, and Agrochemistry

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