Statistical Analysis of the Relationship between Translation Initiation AUG Context and Gene Expression Level in Humans

Hitoshi MIYASAKA; Shozo KANAI; Satoshi TANAKA; Hideo AKIYAMA; Masahiko HIRANO

doi:10.1271/bbb.66.667

Biochemistry & Molecular Biology Notes

Statistical Analysis of the Relationship between Translation Initiation AUG Context and Gene Expression Level in Humans

Hitoshi MIYASAKA, Shozo KANAI, Satoshi TANAKA, Hideo AKIYAMA, Masahiko HIRANO

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Keywords: AUG context, translation initiation, consensus sequence, human, natural selection

JOURNAL FREE ACCESS

2002 Volume 66 Issue 3 Pages 667-669

DOI https://doi.org/10.1271/bbb.66.667

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Abstract

The preference for the optimal nucleotide of the mammalian translation initiation AUG context [GCCGCC(A/G)CCaugG] is generally more pronounced in the highly expressed genes than in the transcription factor genes at the −9 through −1 positions in humans. The influence of amino acid preference on the nucleotide choice at the +4 position was also examined.

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