Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Food & Nutrition Science Preliminary Communication
Suppressive Effect of Polysaccharides from the Edible and Medicinal Mushrooms, Lentinus edodes and Agaricus blazei, on the Expression of Cytochrome P450s in Mice
Takashi HASHIMOTOYuji NONAKAKen-ichiro MINATOSachiko KAWAKAMIMasashi MIZUNOItsuko FUKUDAKazuki KANAZAWAHitoshi ASHIDA
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2002 Volume 66 Issue 7 Pages 1610-1614

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Abstract

  To investigate the effects of lentinan from Lentinas edodes and polysaccharides from Agaricus blazei (ABPS) on the expression of cytochrome P450s (CYPs), lentinan (10 mg/kg/day) or ABPS (200 mg/kg/day) was administered to female BALB/c mice four times every other day by intraperitoneal injection. Lentinan and ABPS suppressed both the constitutive and 3-methylcholanthrene-induced CYP1A expression and ethoxyresorufin-O-deethylation activity in the liver.

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© 2002 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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