Effect of α,α-Dialkyl Amino Acids on the Protease Resistance of Peptides

Hiroshi YAMAGUCHI; Hiroaki KODAMA; Satoshi OSADA; Fumio KATO; Masood JELOKHANI-NIARAKI; Michio KONDO

doi:10.1271/bbb.67.2269

Organic Chemistry Note

Effect of α,α-Dialkyl Amino Acids on the Protease Resistance of Peptides

Hiroshi YAMAGUCHI, Hiroaki KODAMA, Satoshi OSADA, Fumio KATO, Masood JELOKHANI-NIARAKI, Michio KONDO

著者情報

キーワード: 2-aminoisobutyric acid, α,α-dialkyl amino acid, peptide antibiotic, protease resistance, trypsin

ジャーナルフリー

2003 年 67 巻 10 号 p. 2269-2272

DOI https://doi.org/10.1271/bbb.67.2269

詳細

抄録

A tryptic [EC 3.4.21.4] digestion assay of 2-aminoisobutyric acid (Aib)-containing peptides was carried out to investigate the effect of α,α-dialkyl amino acid residues on the protease resistance. The introduction of Aib residues to the P1′ positions exhibited a 19-fold higher protease resistance than the peptide with Aib residues introduced to the P2 position or the non-Aib peptide. The peptide having Aib residues introduced to the P1′ and P2 positions resulted in complete resistance.

責任著者(Corresponding author)

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